Unfortunately NO!  The Dictaphone PowerMic II can only be used on a PC and only within Dragon Medical v10.1 and higher. 

After running several test, I found that the PowerMic II will be recognized on MAC and can technically be used as a microphone, however; none of the buttons can be used or programmed. 

Verification Source: In-House Testing

If you have any additional questions, please do not hesitate to contact me.