Yes, you can use the Philips SpeechMike Air on a MAC with a caveat. You will not be able to program/customize any buttons on the SpeechMike Air. Only the SpeechMike II & SpeechMike III (wired version) can be programed via the latest Philips Speech Control for Mac v2.8.260.
Verification Source: In-house testing
Test Date: 08-01-12