On some occasions, a user receives an error message when trying to open up a Dragon roaming user profile.

The roaming user local directory cannot be on a network drive:

It means that your system tried to create a local copy of the master roaming user in a location that may not be accessible to your computer if you should disconnect from the network. Your local roaming user must be accessible to your computer at all times.  In some situations you may have your user directories on a network drive.  You will need to install the local user cache on the on a physical storage device that resides on the PC.

Source:  Nuance ISupport

Updated 9/14/11